Susan A. Kadlubar, PhD
Susan A. Kadlubar, PhD, is currently an Associate Professor, Division of Medical Genetics in the College of Medicine at the University of Arkansas for Medical Sciences and Director of the Pharmacogenomics Core Facility in the Winthrop P. Rockefeller Cancer Institute. Dr. Kadlubar received her doctoral degree in Pharmacology and Toxicology from the University of Arkansas for Medical Sciences. She has extensive experience in both pharmacogenomics (the study of how genetic differences influence response to drugs) and how genetic differences influence how our body’s proteins work (genotype-phenotype studies). She has many years of experience and expertise in the study of pharmacogenetics, and the role of enzymes in metabolism of drugs and carcinogens. Dr. Kadlubar has an active research program in the study of sulfotransferases, and has published on the extent to which polymorphisms in the SULT1A1 gene predict sulfotransferase activity in platelets, a biomarker we have used in case control studies of breast and prostate cancer. Early in her career, she was Principal Investigator (PI) of a study funded by the Department of Defense. This study aimed to assess the impact of tamoxifen treatment on SULT1A1 platelet activity in breast cancer patients treated with tamoxifen and modulation of changes by genotype, and coordinated the patient recruitment and epidemiologic aspects of the study. She initiated the pharmacogenetic study of SULT1A1 and tamoxifen therapy, which was published in the Journal of the National Cancer Institute, and she continues to investigate the biologic basis of the association observed in that study.
Dr. Kadlubar is very passionate about breast cancer research and, along with Dr. Klimberg, serves as the co-PI of the Spit for the Cure Study. In the past 5 years the study has been able to recruit over 20,000 participants!
Dr. Kadlubar believes that women who participate in our studies are heroes in the same way that organ donors are heroes. While saliva may not seem to be remarkable at first look, one sample impacts the lives of countless individuals. Dr. Kadlubar looks forward to your contribution in research by becoming a participant in the study.